A Brief Review on Ultrasound Induced Drug Activation Systems

Jia-Ning Zhang; Yu-Ru Ma; Liu-Tian-Yun Yuan; Shang Jia; Xiao-Miao Yu; Yuan Yuan; Zhi-Yuan Shi

doi:10.1007/s10118-025-3398-3

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A Brief Review on Ultrasound Induced Drug Activation Systems

REVIEW | Updated：2025-10-30

- A Brief Review on Ultrasound Induced Drug Activation Systems
- Chinese Journal of Polymer Science Vol. 43, Issue 11, Pages: 1950-1972(2025)
- Affiliations：
  
  a.School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin 300072, China
  b.State Key Laboratory of Advanced Materials for Intelligent Sensing, Ministry of Science and Technology & Key Laboratory of Organic Integrated Circuit, Ministry·of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China
- Author bio：
  
  yyuan@tju.edu.cn (Y.Y.)
  zhiyuan_shi2023@tju.edu.cn (Z.Y.S.)
- Funds：
- DOI：10.1007/s10118-025-3398-3
  CLC：
- Received：01 May 2025，
  
  Revised：2025-06-06，
  
  Accepted：15 June 2025，
  
  Online First：25 September 2025，
  
  Published：05 November 2025
- Accepted：
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Zhang, J. N.; Ma, Y. R.; Yuan, L. T. Y.; Jia, S.; Yu, X. M.; Yuan, Y.; Shi, Z. Y. A brief review on ultrasound induced drug activation systems. Chinese J. Polym. Sci. 2025, 43, 1950–1972

Jia-Ning Zhang, Yu-Ru Ma, Liu-Tian-Yun Yuan, et al. A Brief Review on Ultrasound Induced Drug Activation Systems[J]. Chinese Journal of Polymer Science, 2025, 43(11): 1950-1972.
Zhang, J. N.; Ma, Y. R.; Yuan, L. T. Y.; Jia, S.; Yu, X. M.; Yuan, Y.; Shi, Z. Y. A brief review on ultrasound induced drug activation systems. Chinese J. Polym. Sci. 2025, 43, 1950–1972 DOI： 10.1007/s10118-025-3398-3.

Jia-Ning Zhang, Yu-Ru Ma, Liu-Tian-Yun Yuan, et al. A Brief Review on Ultrasound Induced Drug Activation Systems[J]. Chinese Journal of Polymer Science, 2025, 43(11): 1950-1972. DOI： 10.1007/s10118-025-3398-3.

摘要

This review systematically investigates the mechanisms of ultrasound-induced cleavage of covalent/non-covalent bonds and ultrasound-induced generation of ROS through nanocarriers. We emphasize the role of ultrasound in drug molecule activation and its unique advantages. Finally

current challenges and future directions are discussed to broaden the application of ultrasound mechanochemistry.

Abstract

Ultrasound (US)

as an efficient and non-invasive trigger

has been extensively explored in drug delivery and has many advantages

such as deep penetration

low invasiveness

and high biochemical precision. These advantages demonstrate the immense clinical potential of ultrasound. This study aimed to provide a comprehensive analysis of ultrasound-induced shear forces that exhibit covalent/non-covalent bond cleavage and reactive oxygen species (ROS)-mediated remote control of nanocarriers. By doing so

we can gain a deeper understanding of the vital role

significant advantages

and untapped potential of ultrasound in molecular-level drug activation. Furthermore

clinical translation faces challenges such as the low drug-loading capacity of polymer chains

frequency compatibility between ultrasound parameters and biological systems

insufficient ROS generation

and biocompatibility of current sonosensitizers. To solve these problems

ultrasound mechanochemistry has emerged as a versatile therapeutic modality to promote the development of medical treatments.

关键词

Keywords

references

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