Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials

Xiao-Bo Deng; Hong-Xiu Wei; Lin Yang; Feng Luo; Zhen Li; Hong Tan; Yan-Chao Wang; Jie-Hua Li

doi:10.1007/s10118-025-3328-4

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Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials

RESEARCH ARTICLE | Updated：2025-04-24

- Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials
- Chinese Journal of Polymer Science Vol. 43, Pages: 1-9(2025)
- Affiliations：
  
  a.College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China
  b.Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610000, China
- Author bio：
  
  wangyanchao@scu.edu.cn (Y.C.W.)
  jiehua_li@scu.edu.cn (J.H.L.)
- Funds：
- DOI：10.1007/s10118-025-3328-4
  CLC：
- Received：24 January 2025，
  
  Revised：19 February 2025，
  
  Accepted：2025-02-26，
  
  Published Online：24 April 2025，
  
  Published：20 May 2025
- Accepted：
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Deng, X. B.; Wei, H. X.; Yang, L.; Luo, F.; Li, Z.; Tan, H.; Wang, Y. C.; Li, J. H. Layered gradient-structured coating with sustained lubricating performance for the surface functionalization of implant materials. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-025-3328-4

Xiao-Bo Deng, Hong-Xiu Wei, Lin Yang, et al. Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials[J/OL]. Chinese journal of polymer science, 2025, 431-9.
Deng, X. B.; Wei, H. X.; Yang, L.; Luo, F.; Li, Z.; Tan, H.; Wang, Y. C.; Li, J. H. Layered gradient-structured coating with sustained lubricating performance for the surface functionalization of implant materials. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-025-3328-4 DOI：

Xiao-Bo Deng, Hong-Xiu Wei, Lin Yang, et al. Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials[J/OL]. Chinese journal of polymer science, 2025, 431-9. DOI： 10.1007/s10118-025-3328-4.

摘要

Abstract

Enhancing the lubricating properties and antibacterial adhesion resistance of implantable medical materials is critical to prevent soft tissue injury during implantation and the formation of bacterial biofilms. Prior studies may have exhibited limitations in the preparation methodologies and long-term stability of coatings for implantable medical materials. In this study

we developed a multilayered hybrid hydrogel coating method based on the rate difference of polymerization initiation on the material surface. The acquired coating with persistent lubrication capability retained its functionality after 2×10

cycles of friction and 21 days of PBS immersion. A quaternary ammonium salt coating with antibacterial properties was introduced to further functionalize the coating. Animal experiments demonstrated that this coating exhibited remarkable effects on delaying encrustation and bacterial colonization. These studies indicate that this simple method of introducing lubricating and antibacterial coatings on catheters is likely to enhance the biocompatibility of medical devices and has broad application prospects in this field of medical devices.

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references

Zander, Z. K.; Becker, M. L. Antimicrobial and antifouling strategies for polymeric medical devices. ACS Macro Lett. 2018 , 7 , 16−25..

Meddings, J. Interventions to reduce urinary catheter use: it worked for them, but will it work for us. BMJ Qual. Saf. 2013 , 22 , 967−971..

Cauda, F.; Cauda, V.; Fiori, C.; Onida, B.; Garrone, E. Heparin coating on ureteral double J stents prevents encrustations: an in vivo case study. J. Endourol. 2008 , 22 , 465−472..

Jamal, M. A.; Hachem, R. Y.; Rosenblatt, J.; McArthur, M. J.; Felix, E.; Jiang, Y.; Tailor, R. C.; Raad, I. In vivo biocompatibility and in vitro efficacy of antimicrobial gendine-coated central catheters. Antimicrob. Agents Chemother . 2015 , 59 , 5611−5618..

Wang, L.; Zhang, S.; Keatch, R.; Corner, G.; Nabi, G.; Murdoch, S.; Davidson, F.; Zhao, Q. In-vitro antibacterial and anti-encrustation performance of silver-polytetrafluoroethylene nanocomposite coated urinary catheters. J. Hosp. Infect . 2019 , 103 , 55−63..

Zhu, Y. C.; Zhou, G. H.; Yuan, X. M.; Li, Z.; Xu, Q.; Zhang, M. Y. Analysis of the effect of ther apy for severe intracranial infection after craniotomy. J. Neurorestoratol. 2024 , 12 , 100092..

Wang, C. H.; Mu, C. D.; Lin, W.; Xiao, H. N. Functional-modified polyurethanes for rendering surfaces antimicrobial: an overview. Adv. Colloid Interface Sci. 2020 , 283 , 102235..

Liu, G. Q.; Feng, Y.; Zhao, N.; Chen, Z.; Shi, J. Q.; Zhou, F. Polymer-based lubricating materials for functional hydration lubrication. Chem. Eng. J. 2022 , 429 , 132324..

Milo, S.; Hathaway, H.; Nzakizwanayo, J.; Alves, D. R.; Esteban, P. P.; Jones, B. V.; Jenkins, A. T. A. Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage. J. Mater. Chem. B 2017 , 5 , 5403−5411..

Neoh, K. G.; Li, M.; Kang, E. T.; Chiong, E.; Tambyah, P. A. Surface modification strategies for combatingcatheter-related complications: recent advances and challenges. J. Mater. Chem. B 2017 , 5 , 2045−2067..

Wang, R.; Neoh, K. G.; Kang, E. T.; Tambyah, P. A.; C hiong, E. Antifouling coating with controllable and sustained silver release for long-term inhibition of infection and encrustation in urinary catheters. J. Biomed. Mater. Res. Part B Appl. Biomater. 2015 , 103 , 519−528..

Shalom, Y.; Perelshtein, I.; Perkas, N.; Gedanken, A.; Banin, E. Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections. Nano Res. 2017 , 10 , 520−533..

Srisang, S.; Wongsuwan, N.; Boongird, A.; Ungsurungsie, M.; Wanasawas, P.; Nasongkla, N. Multilayer nanocoating of Foley urinary catheter by chlorhexidine-loaded nanoparticles for prolonged release and anti-infection of urinary tract. Int. J. Polym. Mater. Polym. Biomater. 2020 , 69 , 1081−1089..

He, M. R.; Gao, K.; Zhou, L. J.; Jiao, Z. W.; Wu, M. Y.; Cao, J. L.; You, X. D.; Cai, Z. Y.; Su, Y. L.; Jiang, Z. Y. Zwitterionic materials for antifouling membrane surface construction. Acta Biomater. 2016 , 40 , 142−152..

Badv, M.; Bayat, F.; Weitz, J. I.; Didar, T. F. Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants. Biomaterials 2020 , 258 , 120291..

Zhao, J.; Shi, Q.; Luan, S. F.; Song, L. J.; Yang, H. W.; Shi, H. C.; Jin, J.; Li, X. L.; Yin, J. H.; Stagnaro, P. Improved biocompatibility and antifouling property of polypropylene non-woven fabric membrane by surface grafting zwitterionic polymer. J. Membr. Sci. 2011 , 369 , 5−12..

Li, L. H.; Yang, L.; Liao, Y. B.; Yu, H. C.; Liang, Z.; Zhang, B.; Lan, X. R.; Luo, R. F.; Wang, Y. B. Superhydrophilic versus normal polydopamine coating: a superior and robust platform for synergistic antibacterial and antithrombotic properties. Chem. Eng. J. 2020 , 402 , 126196..

Zou, Z.; Xu, X.; Zhao, H. T.; Cheng, J. N.; He, W. W.; Zhang, L. F.; Cheng, Z. P. Manipulating the phase transition behavior of dual temperature-responsive block copolymers by adjusting composition and sequence. Chinese J. Polym. Sci . 2024 , 42 , 176−187..

Qian, Y. F.; Zhao, J.; Liu, L.; Hu, H.; Wang, B.; Zhang, H. Y. Bioinspired phosphorylcholine coating for surface functionalization of interventional biomedical implants with bacterial resistance and anti-encrustation properties. Langmuir 2022 , 38 , 3597−3606..

Peng, W.; Liu, P. M.; Zhang, X.; Peng, J. M.; Gu, Y. H.; Dong, X. H.; Ma, Z. Z.; Liu, P. S.; Shen, J. Multi-functional zwitterionic coating for silicone-based biomedical devices. Chem. Eng. J. 2020 , 398 , 125663..

Liu, P. M.; Huang, T.; Liu, P. S.; Shi, S. F.; Chen, Q.; Li, L.; Shen, J. Zwitterionic modification of polyurethane membranes for enhancing the anti-fouling property. J. Colloid Interface Sci. 2016 , 480 , 91−101..

Kerber, S. J.; Bruckner, J. J.; Wozniak, K.; Seal, S.; Hardcastle, S.; Barr, T. L. The nature of hydrogen in X-ray photoelectron spectroscopy: General patterns from hydroxides to hydrogen bonding. J. Vac. Sci. Technol. A Vac. Surf. Films 1996 , 14 , 1314−1320..

Song, Y. Q.; Gao, Y. L.; Pan, Z. C.; Zhang, Y.; Li, J. H.; Wang, K. J.; Li, J. S.; Tan, H.; Fu, Q. Preparation and characterization of controlled heparin release waterborne polyurethane coating systems. Chinese J. Polym. Sci . 2016 , 34 , 679−687..

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