SYNTHESIS OF POLY(GLUTAMIC ACID-<italic style="font-style: italic">co</italic>-ASPARTIC ACID) <italic style="font-style: italic">VIA</italic> COMBINATION OF <italic style="font-style: italic">N</italic>-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION

Wei-xi Yang; Ling-ling Wang; Han Zhu; Ri-wei Xu; Yi-xian Wu

doi:10.1007/s10118-013-1363-z

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SYNTHESIS OF POLY(GLUTAMIC ACID-co-ASPARTIC ACID) VIA COMBINATION OF N-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION

PAPER | Updated：2023-01-03

- SYNTHESIS OF POLY(GLUTAMIC ACID-co-ASPARTIC ACID) VIA COMBINATION OF N-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION
- Chinese Journal of Polymer Science Vol. 31, Issue 12, Pages: 1706-1716(2013)
- Affiliations：
  
  State Key Laboratory of Chemical Resource, Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education), Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  **Yi-xian Wu (吴一弦), E-mail: yxwu@263.net
- Funds：
- DOI：10.1007/s10118-013-1363-z
  CLC：
- Received：11 January 2013，
  
  Revised：2013-05-09，
  
  Accepted：10 May 2013，
  
  Published：2013-12
- Accepted：
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Wei-xi Yang, Ling-ling Wang, Han Zhu, et al. SYNTHESIS OF POLY(GLUTAMIC ACID-co-ASPARTIC ACID) VIA COMBINATION OF N-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION[J]. Chinese Journal of Polymer Science, 2013, 31(12): 1706-1716. DOI: 10.1007/s10118-013-1363-z.
DOI：

Wei-xi Yang, Ling-ling Wang, Han Zhu, et al. SYNTHESIS OF POLY(GLUTAMIC ACID-co-ASPARTIC ACID) VIA COMBINATION OF N-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION[J]. Chinese Journal of Polymer Science, 2013, 31(12): 1706-1716. DOI: 10.1007/s10118-013-1363-z. DOI：

摘要

Abstract

The random copolymers of glutamic acid (LG) and aspartic acid (ASP)

poly(LG-

-ASP)

with designed compositions could be successfully synthesized

via

combination of

-carboxyanhydride ring opening copolymerization with debenzylation. Ring opening copolymerizations of

-benzyl-L-glutamate

-carboxyanhydride (BLG-NCA) and

-benzyl-L-aspartate

-carboxyanhydride (BLA-NCA) were carried out by using different amines including triethylamine (TEA)

diethylamine

-hexylamine (NHA)

triphenylamine

diphenylamine or aniline as initiators. All the 6 amines were highly efficient to get well-defined poly(BLG-

-BLA) copolymers with designed compositions although the polymerizations proceeded

via

different mechanisms (normal amine mechanism or/and activated monomer mechanism)

which are based on chemical structure of amines. The molecular weights of poly(BLG-

-BLA) copolymers could be mediated by both TEA concentration and polymerization time. Then

debenzylation of poly(BLG-

-BLA) copolymers was conducted to prepare the corresponding hydrophilic random copolymers of poly(LG-

-ASP) with α-subunit structure in ASP structural units. The contents of LG structural units in poly(LG-

-ASP) copolymers matched with those of BLG-NCA in NCA-monomer feeds in ring opening copolymerizations initiated by NHA or TEA and were closed to the theoretical line. The diblock copolymer of poly(BLG-

-BLA) could also be synthesized via living NCA ring opening copolymerization by sequential addition of BLGNCA and BLA-NCA.

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SYNTHESIS OF POLY(GLUTAMIC ACID-co-ASPARTIC ACID) VIA COMBINATION OF N-CARBOXYANHYDRIDE RING OPENING POLYMERIZATION WITH DEBENZYLATION

DOI：10.1007/s10118-013-1363-z

摘要

Abstract

关键词

Keywords

references