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Citation: Wang, J. H.; Chen, R.; Zhao, Z. Q.; Shen, J.; Yang, H.; Luo, Y.; Chen, G. J.; Chen, H.; Brash, J. L. Feasible fabrication of hollow micro-vesicles by non-amphiphilic macromolecules based on interfacial cononsolvency. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-021-2541-z doi: 10.1007/s10118-021-2541-z shu

Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency

  • a.

    State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

  • b.

    Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China

  • c.

    Department of Chemical Engineering and School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada

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  • Herein we present a new perspective showing that water-soluble liquids, when added to water, undergo transient emulsification before complete dissolution. Thus, non-amphiphilic macromolecules can self-assemble at the two-miscible-phase interface when cononsolvent effect appears. A representative case shown here is that when poly(N-isopropylacrylamide) (PNIPAm), prepared by aqueous radical polymerization, in methanol solution is added into water, the polymer chains rapidly self-assemble into hollow micro-vesicles based on the cononsolvency at water/methanol interface. This finding provides a subtle strategy to prepare hollow micro-vesicles by non-amphiphilic polymers without template participating. We proposed a new concept “interfacial cononsolvency” to describe the formation process. Due to the easy modification process, sugar-contained PNIPAm chains are synthesized by copolymerization. As an application example, it is shown that these sugar-contained PNIPAm chains can afford “sweet” micro-vesicles (containing glucose residues). And the “sweet” micro-vesicles can well mimick the protocells which are involved in the recognition of bacteria.
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